Affiliation:
1. BioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, 21000 Novi Sad, Serbia
Abstract
Mesoporous silica nanoparticles (MSNs) exhibit highly beneficial characteristics for devising efficient biosensors for different analytes. Their unique properties, such as capabilities for stable covalent binding to recognition groups (e.g., antibodies or aptamers) and sensing surfaces, open a plethora of opportunities for biosensor construction. In addition, their structured porosity offers capabilities for entrapping signaling molecules (dyes or electroactive species), which could be released efficiently in response to a desired analyte for effective optical or electrochemical detection. This work offers an overview of recent research studies (in the last five years) that contain MSNs in their optical and electrochemical sensing platforms for the detection of cancer biomarkers, classified by cancer type. In addition, this study provides an overview of cancer biomarkers, as well as electrochemical and optical detection methods in general.
Funder
European Union’s Horizon 2020 research and innovation program
Ministry of Education, Science, and Technological Development of the Republic of Serbia
Reference137 articles.
1. Synthesis of Mesoporous Silica Nanoparticles;Wu;Chem. Soc. Rev.,2013
2. Narayan, R., Nayak, U.Y., Raichur, A.M., and Garg, S. (2018). Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances. Pharmaceutics, 10.
3. Synthesis of Nanoscale Mesoporous Silica Spheres with Controlled Particle Size;Nooney;Chem. Mater.,2002
4. Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles;Kankala;Adv. Mater.,2020
5. Gated Silica Mesoporous Materials in Sensing Applications;Pascual;ChemistryOpen,2015