Regulation of the Host Immune Microenvironment in Periodontitis and Periodontal Bone Remodeling

Author:

Han Nannan12ORCID,Liu Yitong12,Du Juan12,Xu Junji12,Guo Lijia3,Liu Yi12

Affiliation:

1. Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China

2. Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

3. Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China

Abstract

The periodontal immune microenvironment is a delicate regulatory system that involves a variety of host immune cells including neutrophils, macrophages, T cells, dendritic cells and mesenchymal stem cells. The dysfunction or overactivation of any kind of local cells, and eventually the imbalance of the entire molecular regulatory network, leads to periodontal inflammation and tissue destruction. In this review, the basic characteristics of various host cells in the periodontal immune microenvironment and the regulatory network mechanism of host cells involved in the pathogenesis of periodontitis and periodontal bone remodeling are summarized, with emphasis on the immune regulatory network that regulates the periodontal microenvironment and maintains a dynamic balance. Future strategies for the clinical treatment of periodontitis and periodontal tissue regeneration need to develop new targeted synergistic drugs and/or novel technologies to clarify the regulatory mechanism of the local microenvironment. This review aims to provide clues and a theoretical basis for future research in this field.

Funder

National Nature Science Foundation of China

Innovation Research Team Project of Beijing Stomatological Hospital, Capital Medical University

Innovation Foundation of Beijing Stomatological Hospital, Capital Medical University

Beijing Municipal Administration of Hospitals’ Youth Programme

Beijing Stomatological Hospital, Capital Medical University Young Scientist Program

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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