Affiliation:
1. School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China
Abstract
The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest immune organ, while numerous microorganisms coexist with the host. It is well known that the complex interactions between the gut microbiota and the host’s immune system inevitably affect the function of other organs, creating an “axis” between them. During the past few years, a new technique based mainly on microfluidics and cell biology has been developed to emulate the structure, function, and microenvironment of the human gut, called the “gut-on-chip”. This microfluidic chip provides insight into key aspects of gut function in health and disease, such as the gut–brain axis, gut–liver axis, gut–kidney axis, and gut–lung axis. In this review, we first describe the basic theory of the gut axis and the various composition and parameter monitoring of the gut microarray systems, as well as summarize the development and emerging advances in the gut–organ-on-chip, with a focus on the host-gut flora and nutrient metabolism, and highlight their role in pathophysiological studies. In addition, this paper discusses the challenges and prospects for the current development and further use of the gut–organ-on-chip platform.
Funder
National Key Research and Development Program
General Plan of the Shaanxi Province
Key Industrial Chain Projects of the Shaanxi Province—Agricultural Field
Industrialization projects of the Education Department of the Shaanxi Province
Project from Weiyang Technology Bureau
Xi’an City Innovation Plan—Agricultural Field
project from Qinchuang Yuan “Scientist& Engineers” Team
Project from the Ningxia Zhong Ning Goji Industry Innovation Research Institute
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
17 articles.
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