Multifaceted Nature of DNA Polymerase θ-Reference-Cited by-同舟云学术

Multifaceted Nature of DNA Polymerase θ

Published:2023-02-10 Issue:4 Volume:24 Page:3619
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Kruchinin Alexander A.¹^ORCID,Makarova Alena V.¹^ORCID

Affiliation:

1. National Research Center “Kurchatov Institute”, Institute of Molecular Genetics, Kurchatov Sq. 2, 123182 Moscow, Russia

Abstract

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/4/3619/pdf

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