Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives-Reference-Cited by-同舟云学术

Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives

Published:2023-02-07 Issue:4 Volume:24 Page:3319
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Olczak Andrzej¹^ORCID,Pawlak Tomasz²^ORCID,Kałużyńska Sylwia¹,Gobis Katarzyna³^ORCID,Korona-Głowniak Izabela⁴^ORCID,Suśniak Katarzyna⁴^ORCID,Zaborowski Marcin⁵,Szczesio Małgorzata¹^ORCID

Affiliation:

1. Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland

2. Centre of Molecular and Macromolecular Studies, Polish Academy of Science, Sienkiewicza 112, 90-363 Lodz, Poland

3. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gen. Hallera Ave. 107, 80-416 Gdańsk, Poland

4. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, Chodźki Street 1, 20-093 Lublin, Poland

5. Dean Office’s, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 114, 90-543 Lodz, Poland

Abstract

Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/4/3319/pdf

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