Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective-Reference-Cited by-同舟云学术

Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective

Published:2023-02-20 Issue:4 Volume:24 Page:4187
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Lv Peiyun¹,Wan Jinlu¹,Zhang Chunting¹,Hina Aiman¹^ORCID,Al Amin G M²^ORCID,Begum Naheeda¹,Zhao Tuanjie¹^ORCID

Affiliation:

1. National Center for Soybean Improvement, Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China

2. Department of Botany, Jagannath University, Dhaka 1100, Bangladesh

Abstract

Domain of unknown function (DUF) is a general term for many uncharacterized domains with two distinct features: relatively conservative amino acid sequence and unknown function of the domain. In the Pfam 35.0 database, 4795 (24%) gene families belong to the DUF type, yet, their functions remain to be explored. This review summarizes the characteristics of the DUF protein families and their functions in regulating plant growth and development, generating responses to biotic and abiotic stress, and other regulatory roles in plant life. Though very limited information is available about these proteins yet, by taking advantage of emerging omics and bioinformatic tools, functional studies of DUF proteins could be utilized in future molecular studies.

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Jiangsu Seed Industry Revitalization Project

Jiangsu Collaborative Innovation Centre for Modern Crop Production

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/4/4187/pdf

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