Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature-Reference-Cited by-同舟云学术

Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature

Published:2023-08-28 Issue:9 Volume:13 Page:1821
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Guglielmo Priscilla¹,Alongi Pierpaolo²^ORCID,Baratto Lucia³,Abenavoli Elisabetta⁴^ORCID,Buschiazzo Ambra⁵,Celesti Greta⁶,Conte Miriam⁷^ORCID,Filice Rossella⁸,Gorica Joana⁷,Jonghi-Lavarini Lorenzo⁹,Lanzafame Helena¹⁰¹¹^ORCID,Laudicella Riccardo⁸^ORCID,Librando Maria⁶,Linguanti Flavia¹²^ORCID,Mattana Francesco¹³,Miceli Alberto¹⁴,Olivari Laura¹⁵^ORCID,Piscopo Leandra¹⁶^ORCID,Romagnolo Cinzia¹⁷,Santo Giulia¹⁸^ORCID,Vento Antonio¹⁹,Volpe Fabio¹⁶^ORCID,Evangelista Laura²⁰²¹^ORCID

Affiliation:

1. Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy

2. Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90127 Palermo, Italy

3. Department of Radiology, Division of Pediatric Radiology, Lucile Packard Children’s Hospital, Stanford University, Stanford, CA 94304, USA

4. Nuclear Medicine Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy

5. Nuclear Medicine Division, Santa Croce and Carle Hospital, 12100 Cuneo, Italy

6. Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, 98122 Messina, Italy

7. Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy

8. Unit of Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo, 90133 Palermo, Italy

9. Department of Nuclear Medicine, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy

10. Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, 45147 Essen, Germany

11. German Cancer Consortium (DKTK), Partner Site University Hospital Essen, 45147 Essen, Germany

12. Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy

13. Division of Nuclear Medicine, IEO European Institute of Oncology IRCSS, 20141 Milan, Italy

14. Nuclear Medicine Unit, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy

15. Nuclear Medicine Unit, IRCCS Ospedale Sacro Cuore Don Calabria, 37024 Negrar, Italy

16. Department of Advanced Biomedical Sciences, University Federico II, 80138 Naples, Italy

17. Department of Nuclear Medicine, “Ospedali Riuniti” Hospital, 60126 Ancona, Italy

18. Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, Italy

19. Nuclear Medicine Department, ASP 1-P.O. San Giovanni di Dio, 92100 Agrigento, Italy

20. Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy

21. IRCCS Humanitas Research Hospital, 20089 Milan, Italy

Abstract

FAPI-based radiopharmaceuticals are a novel class of tracers, mainly used for PET imaging, which have demonstrated several advantages over [18F]FDG, especially in the case of low-grade or well-differentiated tumors. We conducted this systematic review to evaluate all the studies where a head-to-head comparison had been performed to explore the potential utility of FAPI tracers in clinical practice. FAPI-based radiopharmaceuticals have shown promising results globally, in particular in detecting peritoneal carcinomatosis, but studies with wider populations are needed to better understand all the advantages of these new radiopharmaceuticals.

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Link

https://www.mdpi.com/2075-1729/13/9/1821/pdf

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