Highly Stretchable, Self-Healing, Injectable and pH Responsive Hydrogel from Multiple Hydrogen Bonding and Boron-Carbohydrate Interactions-Reference-Cited by-同舟云学术

Highly Stretchable, Self-Healing, Injectable and pH Responsive Hydrogel from Multiple Hydrogen Bonding and Boron-Carbohydrate Interactions

Published:2023-09-01 Issue:9 Volume:9 Page:709
ISSN:2310-2861
Container-title:Gels
language:en
Short-container-title:Gels

Author:

Peng Yi-Yang¹²^ORCID,Cheng Qiuli²,Wu Meng¹,Wang Wenda¹,Zhao Jianyang³,Diaz-Dussan Diana¹^ORCID,McKay Michelle¹,Zeng Hongbo¹^ORCID,Ummartyotin Sarute⁴⁵,Narain Ravin¹^ORCID

Affiliation:

1. Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada

2. School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China

3. School of Biomedical Sciences and Engineering Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China

4. Department of Materials and Textile Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120, Thailand

5. Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Bangkok 10330, Thailand

Abstract

A simple and cost-effective method for the fabrication of a safe, dual-responsive, highly stretchable, self-healing and injectable hydrogel is reported based on a combination of dynamic boronate ester bonds and hydrogen bonding interactions. The mechanical properties of the hydrogel are tunable by adjusting the molar ratios between sugar moieties on the polymer and borax. It was remarkable to note that the 2:1 ratio of sugar and borate ion significantly improves the mechanical strength of the hydrogel. The injectability, self-healing and stretchability properties of the hydrogel were also examined. In addition, the impact of the variation of the pH and the addition of free sugar responsiveness of the hydrogel was studied. High MRC-5 cell viability was noticed by the 3D live/dead assay after 24 h cell culture within the hydrogel scaffold. Hence, the developed hydrogels have desirable features that warrant their applications for drug delivery, scaffolds for cell and tissue engineering.

Funder

Natural Sciences and Engineering Council of Canada

Thammasat University Research Unit in Textile and Polymer Chemistry

National Research Council of Thailand

Publisher

MDPI AG

Subject

Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering

Link

https://www.mdpi.com/2310-2861/9/9/709/pdf

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