A Review of MDA-5 Dermatomyositis and Associated Interstitial Lung Disease-Reference-Cited by-同舟云学术

A Review of MDA-5 Dermatomyositis and Associated Interstitial Lung Disease

Published:2024-02-28 Issue:1 Volume:4 Page:33-48
ISSN:2674-0621
Container-title:Rheumato
language:en
Short-container-title:Rheumato

Author:

Bhandari Sambhawana¹^ORCID,Zickuhr Lisa¹^ORCID,Baral Maun Ranjan²,Bhalla Sanjeev³,Jones Heather⁴,Bucelli Robert⁵,Sen Deepali¹

Affiliation:

1. Division of Rheumatology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA

2. Division of Hospital Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA

3. Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA

4. Meramec Dermatology, St. Louis, MO 63110, USA

5. Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA

Abstract

Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis (DM) is noteworthy for its association with rapidly progressive interstitial lung disease (RP-ILD), vasculopathy, and distinctive cutaneous features. First identified in a Japanese cohort in 2005, MDA-5 DM carries a significant mortality risk, emphasizing the crucial need for early diagnosis. This review explores the pathogenesis, clinical presentation, diagnosis, management, and prognosis of MDA-5 DM and ILD and includes new research and recommendations regarding disease management.

Publisher

MDPI AG

Link

https://www.mdpi.com/2674-0621/4/1/4/pdf

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