Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children

Author:

Fialho Eder M. S.1ORCID,Veras Emanoel M.2ORCID,Jesus Caroline M. de3,Gomes Líllian N.4,Khouri Ricardo5,Sousa Patrícia S.6,Ribeiro Marizélia R. C.7,Batista Rosângela F. L.8,Costa Luciana C.8,Nascimento Flávia R. F.19,Silva Antônio A. M.8,Soeiro-Pereira Paulo V.19ORCID

Affiliation:

1. Health Sciences Graduate Program, Biological and Health Sciences Center, Federal University of Maranhão, São Luís 65080-805, MA, Brazil

2. Medical School, Federal University of Maranhão, São Luís 65080-805, MA, Brazil

3. Health and Technology Graduate Program, Biological and Health Sciences Center, Federal University of Maranhão, São Luís 65080-805, MA, Brazil

4. Department of Immunology, University of São Paulo, São Paulo 05508-000, SP, Brazil

5. Gonçalo Moniz Research Institute, FIOCRUZ-Bahia, Salvador 40296-710, BA, Brazil

6. Reference Center on Neurodevelopment, Assistance and Rehabilitation of Children/NINAR—State Department of Health of the State of Maranhão, São Luís 65077-357, MA, Brazil

7. Department of Medicine III, Federal University of Maranhão, São Luís 65020-240, MA, Brazil

8. Department of Public Health, Federal University of Maranhão, São Luís 65020-060, MA, Brazil

9. Department of Pathology, Federal University of Maranhão, São Luís 65065-545, MA, Brazil

Abstract

Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers’ and children’s immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers’ immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.

Funder

Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior—Brasil

Conselho Nacional de Desenvolvimento e Pesquisa

Fundação de Amparo a Pesquisa do Maranhão

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3