circRNAs in Endometrial Cancer—A Promising Biomarker: State of the Art-Reference-Cited by-同舟云学术

circRNAs in Endometrial Cancer—A Promising Biomarker: State of the Art

Published:2024-06-09 Issue:12 Volume:25 Page:6387
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Włodarczyk Karolina¹^ORCID,Kuryło Weronika¹,Pawłowska-Łachut Anna¹^ORCID,Skiba Wiktoria¹^ORCID,Suszczyk Dorota¹^ORCID,Pieniądz Paulina¹²^ORCID,Majewska Małgorzata³^ORCID,Boniewska-Bernacka Ewa⁴,Wertel Iwona¹^ORCID

Affiliation:

1. Independent Laboratory of Cancer Diagnostics and Immunology, Department of Oncological Gynaecology and Gynaecology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland

2. Department of Virology and Immunology, Institute of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland

3. Department of Industrial and Environmental Microbiology, Institute of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland

4. Medical Department, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052 Opole, Poland

Abstract

Endometrial cancer (EC) is one of the most common malignant tumors among women in the 21st century, whose mortality rate is increasing every year. Currently, the diagnosis of EC is possible only after a biopsy. However, it is necessary to find a new biomarker that will help in both the diagnosis and treatment of EC in a non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical and stable long non-coding RNAs (lncRNAs) molecules, which are abundant in both body fluids and human tissues and are expressed in various ways. Considering the new molecular classification of EC, many studies have appeared, describing new insights into the functions and mechanisms of circRNAs in EC. In this review article, we focused on the problem of EC and the molecular aspects of its division, as well as the biogenesis, functions, and diagnostic and clinical significance of circRNAs in EC.

Funder

Medical University of Lublin

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/12/6387/pdf

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