Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury-Reference-Cited by-同舟云学术

Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury

Published:2024-06-14 Issue:12 Volume:25 Page:6553
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Czyżewski Wojciech¹²^ORCID,Litak Jakub³^ORCID,Sobstyl Jan⁴^ORCID,Mandat Tomasz¹,Torres Kamil⁵,Staśkiewicz Grzegorz⁶

Affiliation:

1. Department of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, ul. W.K. Roentgena 5, 02-781 Warsaw, Poland

2. Department of Didactics and Medical Simulation, Medical University of Lublin, 20-954 Lublin, Poland

3. Department of Clinical Immunology, Medical University of Lublin, 20-954 Lublin, Poland

4. Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-954 Lublin, Poland

5. Department of Plastic, Reconstructive Surgery with Microsurgery, Medical University of Lublin, 20-954 Lublin, Poland

6. Department of Human, Clinical and Radiological Anatomy, Medical University, 20-954 Lublin, Poland

Abstract

Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/12/6553/pdf

Reference162 articles.

1. Demlie, T.A., Alemu, M.T., Messelu, M.A., Wagnew, F., and Mekonen, E.G. (2023). Incidence and predictors of mortality among traumatic brain injury patients admitted to Amhara region Comprehensive Specialized Hospitals, northwest Ethiopia, 2022. BMC Emerg. Med., 23.

2. Epidemiology of Chronic Effects of Traumatic Brain Injury;Pugh;J. Neurotrauma,2021

3. Prevalence of Disability Associated with Head Injury with Loss of Consciousness in Adults in the United States: A Population-Based Study;Schneider;Neurology,2021

4. Keating, C.E., and Cullen, D.K. (2021). Mechanosensation in traumatic brain injury. Neurobiol. Dis., 148.

5. Physical and psychological long-term outcome after traumatic brain injury in children and adult patients;Andruszkow;Health Qual. Life Outcomes,2014