Signaling Role of Pericytes in Vascular Health and Tissue Homeostasis

Author:

Fazio Antonietta1ORCID,Neri Irene1,Koufi Foteini-Dionysia1ORCID,Marvi Maria Vittoria1ORCID,Galvani Andrea12,Evangelisti Camilla1ORCID,McCubrey James A.3ORCID,Cocco Lucio1ORCID,Manzoli Lucia1,Ratti Stefano1ORCID

Affiliation:

1. Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy

2. Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, 61029 Urbino, Italy

3. Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA

Abstract

Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with endothelial cells. These cells are known for their intriguing properties due to their heterogeneity in tissue distribution, origin, and multifunctional capabilities. Specifically, pericytes are essential in regulating blood flow, promoting angiogenesis, and supporting tissue homeostasis and regeneration. These multifaceted roles draw on pericytes’ remarkable ability to respond to biochemical cues, interact with neighboring cells, and adapt to changing environmental conditions. This review aims to summarize existing knowledge on pericytes, emphasizing their versatility and involvement in vascular integrity and tissue health. In particular, a comprehensive view of the major signaling pathways, such as PDGFβ/ PDGFRβ, TGF-β, FOXO and VEGF, along with their downstream targets, which coordinate the behavior of pericytes in preserving vascular integrity and promoting tissue regeneration, will be discussed. In this light, a deeper understanding of the complex signaling networks defining the phenotype of pericytes in healthy tissues is crucial for the development of targeted therapies in vascular and degenerative diseases.

Funder

Ministry of University and Research (MUR), National Recovery and Resilience Plan

Publisher

MDPI AG

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