Author:
Kundar Rajeshwari,Gokarn Karuna
Abstract
Rapidly emerging drug-resistant superbugs, especially Gram-negative bacteria, pose a serious threat to healthcare systems all over the globe. Newer strategies are being developed to detect and overcome the arsenal of weapons that these bacteria possess. The development of antibiotics is time-consuming and may not provide full proof of action on evolving drug-resistant pathogens. The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) systems are promising in curbing drug-resistant bacteria. This review focuses on the pathogenesis of Gram-negative bacteria, emergence of antimicrobial drug resistance, and their treatment failures. It also draws attention to the present status of the CRISPR-Cas system in diagnosisand treatment of Gram-negative bacterial infections.
Funder
Sir H.N. Medical Research Society, Sir H.N. Reliance Foundation Hospital & Research Centre
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference168 articles.
1. Pacios, O., Blasco, L., Bleriot, I., Fernandez-Garcia, L., González Bardanca, M., Ambroa, A., López, M., Bou, G., and Tomás, M. (2020). Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics, 9.
2. Centers for Disease Control and Prevention (2022, August 02). Antibiotic Resistance Threats in the United States, 2019, Available online: https://www.cdc.gov/drugresistance/biggest-threats.html.
3. Antimicrobial resistance—Mechanisms and its clinical significance;Abushaheen;Dis. Mon.,2020
4. Epistasis between antibiotic tolerance, persistence, and resistance mutations;Brauner;Proc. Natl. Acad. Sci. USA,2019
5. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE;Rice;J. Infect. Dis.,2008
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献