Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Author:

Chang Sing-Ya,Lee Chih-Chun,Chang Ming-LingORCID,Teng Wen-Chieh,Hsiao Chao-Yang,Yu Han-HuaORCID,Hsieh Meng-Ju,Chan Tien-MingORCID

Abstract

Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

Funder

the Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou and Chang Gung Research Database

Publisher

MDPI AG

Subject

General Medicine

Reference29 articles.

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5. Zhang, G., Li, X., Sun, G., Cao, Y., Gao, N., and Qi, W. (2020). Clinical analysis of Kimura’s disease in 24 cases from China. BMC Surg., 20.

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