Targeting SARS-CoV-2 Non-Structural Proteins-Reference-Cited by-同舟云学术

Targeting SARS-CoV-2 Non-Structural Proteins

Published:2023-08-20 Issue:16 Volume:24 Page:13002
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Tam Donald¹,Lorenzo-Leal Ana C.¹,Hernández Luis Ricardo²^ORCID,Bach Horacio¹^ORCID

Affiliation:

1. Division of Infectious Disease, Department of Medicine, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada

2. Laboratorio de Investigación Fitoquímica, Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, Ex Hacienda Sta. Catarina Mártir S/N, San Andrés Cholula 72810, Mexico

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.

Funder

Canadian Institutes of Health Research

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/16/13002/pdf

Reference106 articles.

1. The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A review of the current global status;Bchetnia;J. Infect. Public Health,2020

2. SARS-CoV-2: From its discovery to genome structure, transcription, and replication;Brant;Cell Biosci.,2021

3. Yadav, R., Chaudhary, J.K., Jain, N., Chaudhary, P.K., Khanra, S., Dhamija, P., Sharma, A., Kumar, A., and Handu, S. (2021). Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19. Cells, 10.

4. Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2;Yan;Cell Res.,2021

5. Low, Z.Y., Zabidi, N.Z., Yip, A.J.W., Puniyamurti, A., Chow, V.T.K., and Lal, S.K. (2022). SARS-CoV-2 non-structural proteins and their roles in host immune evasion. Viruses, 14.

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77;International Journal of Biological Macromolecules;2024-09

2. Repurposing of antimycobacterium drugs for COVID-19 treatment by targeting SARS CoV-2 main protease: An in-silico perspective;Gene;2024-09

3. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors;Journal of Medicinal Chemistry;2024-06-13

4. Inhibition of SARS-CoV-2 Nsp9 ssDNA-Binding Activity and Cytotoxic Effects on H838, H1975, and A549 Human Non-Small Cell Lung Cancer Cells: Exploring the Potential of Nepenthes miranda Leaf Extract for Pulmonary Disease Treatment;International Journal of Molecular Sciences;2024-06-01

5. A Low-cost High-throughput Targeted Sequencing for the Accurate Detection of Respiratory Tract Pathogen;International Journal of Clinical Virology;2024-03-12