Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis-Reference-Cited by-同舟云学术

Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis

Published:2023-05-31 Issue:6 Volume:13 Page:927
ISSN:2075-4426
Container-title:Journal of Personalized Medicine
language:en
Short-container-title:JPM

Author:

Marijić Blažen¹²³^ORCID,Tudor Filip²³^ORCID,Janik Stefan⁴^ORCID,Grasl Stefan⁴,Frommlet Florian⁵,Maržić Diana³⁶,Hadžisejdić Ita³⁷^ORCID,Vukelić Jelena³⁶,Braut Tamara²³,Velepič Marko²³,Erovic Boban M.¹^ORCID

Affiliation:

1. Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria

2. Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

3. Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia

4. Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, 1090 Vienna, Austria

5. Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medical University Vienna, 1090 Vienna, Austria

6. Department of Audiology and Phoniatrics, Clinical Hospital Centre Rijeka, 51000 Rijeka, Croatia

7. Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

Abstract

Purpose: We conducted an outcome analysis on surgically treated laryngeal squamous cell carcinoma (LSCC) patients. Methods: A multicenter retrospective study with 352 patients was analyzed. A new nomogram that incorporates age, T- and N-classification, and treatment was created. Results: Recurrence was observed in 65 (18.5%) patients after a mean time of 16.5 months. After 60 months, 91 (25.9%) of patients developed secondary primary tumors (SPT), most commonly in the lungs (n = 29; 8.2%) followed by other head and neck cancers (n = 21; 6.0%). Notably, the mean time to occurrence of secondary head and neck cancers was twice that of lung cancer (101.1 vs. 47.5 months). Conclusion: Recurrent disease is less common in LSCC patients and appears much earlier than SPT. Because one in every four laryngeal cancer patients develops SPTs within 5–10 years, long-term care and follow-up, including imaging studies, are highly recommended. The nomogram was useful for estimating survival.

Funder

the University of Rijeka

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Link

https://www.mdpi.com/2075-4426/13/6/927/pdf

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