Synthesis and Cholinesterase Inhibitory Potency of 2,3-Indolo-oleanolic Acid and Some Related Derivatives-Reference-Cited by-同舟云学术

Synthesis and Cholinesterase Inhibitory Potency of 2,3-Indolo-oleanolic Acid and Some Related Derivatives

Published:2023-10-18 Issue:4 Volume:2023 Page:M1739
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Petrova Anastasiya V.¹^ORCID,Zueva Irina V.²,Petrov Konstantin A.²

Affiliation:

1. Ufa Federal Research Center, Ufa Institute of Chemistry, Russian Academy of Sciences, 71, Prospect Octyabrya, Ufa 450054, Russia

2. FRC Kazan Scientific Center, Arbuzov Institute of Organic and Physical Chemistry, Russian Academy of Sciences, 8, St. Academician Arbuzov, Kazan 420088, Russia

Abstract

In this study, the synthesis and biological activities of previously and newly synthesized oleanolic acid derivatives containing seven-membered cyclic amines at the C28 position were described. The obtained compounds were fully characterized via 1H and 13C NMR spectroscopy, and the bioactivity was evaluated by Ellman’s method. Among the tested compounds, 2,3-indolo-oleanolic acid was found to be the most active compound with an IC50 value of 0.78 µM against acetylcholinesterase. These results are significant due to the fact that research on the inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by oleanolic acid, in particular indoloderivatives, is limited.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2023/4/M1739/pdf

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