Affiliation:
1. Tianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin Engineering Research Center of Animal Healthy Farming, Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin 300381, China
2. College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China
3. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Abstract
This study was to explore potential SNP loci for reproductive traits in Chinese Holstein cattle and identify candidate genes. Genome-wide Association Study based on mixed linear model was performed on 643 Holstein cattle using GeneSeek Bovine 50 K SNP chip. Our results detected forty significant SNP loci after Bonferroni correction. We identified five genes (VWC2L, STAT1, PPP3CA, LDB3, and CTNNA3) as being associated with pregnancy ratio of young cows, five genes (PAEP, ACOXL, EPAS1, GLRB, and MARVELD1) as being associated with pregnancy ratio of adult cows, and nine genes (PDE1B, SLCO1A2, ARHGAP26, ADAM10, APBB1, MON1B, COQ9, CDC42BPB, MARVELD1, and HPSE2) as being associated with daughter pregnancy rate. Our study may provide valuable insights into identifying genes related to reproductive traits and help promote the application of molecular breeding in dairy cows.
Funder
Special Seed Industry Project of Tianjin Academy of Agricultural Sciences—Research on innovation and Efficient Breeding Technology of Livestock and poultry germplasm Resources
Tianjin Science and Technology Plan Project—Integrated Demonstration of High Quality Beef Cattle Breeding
Tianjin Science and Technology Plan Project—Key Technology Research and germplasm innovation of High-yield Milk Breeding
Subject
Genetics (clinical),Genetics