Affiliation:
1. Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia
Abstract
Diabetes mellitus type 2 (T2DM) is a common chronic condition that presents as unsettled hyperglycemia (HG) and results from insulin resistance (IR) and β-cell dysfunction. T2DM is marked by an increased risk of microvascular and macrovascular complications, all of which can be the cause of increasing mortality. Diabetic nephropathy (DNE), neuropathy (DNU), and retinopathy (DR) are the most common complications of diabetic microangiopathy, while diabetic cardiomyopathy (DCM) and peripheral vascular diseases are the major diabetic macroangiopathy complications. Chalcones (CHs) are in the flavonoid family and are commonly found in certain plant species as intermediate metabolites in the biosynthesis of flavonoids and their derivatives. Natural CHs with different substituents exert diverse therapeutic activities, including antidiabetic ones. However, the therapeutic mechanisms of natural CHs through influencing genes and/or signaling pathways in T2DM complications remain unknown. Therefore, this review summarizes the existing results from experimental models which highlight the mechanisms of natural CHs as therapeutic agents for T2DM complications.
Reference60 articles.
1. Epidemiology of type 2 diabetes—Global burden of disease and forecasted trends;Khan;J. Epidemiol. Glob. Health,2020
2. Safiri, S., Karamzad, N., Kaufman, J.S., Bell, A.W., Nejadghaderi, S.A., Sullman, M.J.M., Moradi-Lakeh, M., Collins, G., and Kolahi, A.-A. (2022). Prevalence, deaths and disability-adjusted-life-years (DALYs) due to type 2 diabetes and its attributable risk factors in 204 countries and territories, 1990-2019: Results from the global burden of disease study 2019. Front. Endocrinol., 13.
3. Guzman-Vilca, W.C., and Carrillo-Larco, R.M. (2024). Number of people with type 2 diabetes mellitus in 2035 and 2050: A modelling study in 188 countries. Curr. Diabetes Rev.
4. Goyal, R., Singhal, M., and Jialal, I. (2023). Type 2 Diabetes, StatPearls.
5. Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links;Oguntibeju;Int. J. Physiol. Pathophysiol. Pharmacol.,2019