Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review-Reference-Cited by-同舟云学术

Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review

Published:2024-07-31 Issue:8 Volume:15 Page:1003
ISSN:2073-4425
Container-title:Genes
language:en
Short-container-title:Genes

Author:

Hassan Mubashir¹,Shahzadi Saba¹,Yasir Muhammad²,Chun Wanjoo²^ORCID,Kloczkowski Andrzej¹³⁴^ORCID

Affiliation:

1. The Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital, Columbus, OH 43205, USA

2. Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea

3. Department of Pediatrics, The Ohio State University School of Medicine, Columbus, OH 43205, USA

4. Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA

Abstract

Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.

Funder

NIH

Publisher

MDPI AG

Link

https://www.mdpi.com/2073-4425/15/8/1003/pdf

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