Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV)—CTN 314-Reference-Cited by-同舟云学术

Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV)—CTN 314

Published:2023-02-13 Issue:2 Volume:15 Page:517
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Zhabokritsky Alice¹,Clarke Rosemarie¹,Rosenes Ron¹,Smith Graham²,Loutfy Mona³,Andany Nisha⁴,Falutz Julian⁵,Klein Marina⁶,Harris Marianne⁷,Guillemi Silvia⁸,Tan Darrell H. S.⁹,Arbess Gordon⁹,Walmsley Sharon¹

Affiliation:

1. Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON M5G 2M9, Canada

2. Maple Leaf Medical Clinic, 14 College St, Toronto, ON M5G 1K2, Canada

3. Women’s College Research Institute, Women’s College Hospital, Toronto, ON M5S 1B2, Canada

4. Sunnybrook Health Science Centre, University of Toronto, Toronto, ON M4N 3M5, Canada

5. Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A3J1, Canada

6. Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada

7. BC Centre for Excellence in HIV/AIDS, University of British Columbia, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada

8. Department of Family Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

9. St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada

Abstract

The Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study, CTN 314, is the first Canadian cohort of people living with HIV aged 65 years and older. The cohort was established with the purpose of characterizing the multidimensional health status of this population and identifying factors influencing healthy aging. The study builds on the World Health Organization (WHO) Aging and Health conceptual framework, generating a comprehensive profile of health domains (physical, social, mental health, cognitive function, and quality of life), health determinants (biologic, personal, and environmental), and HIV-specific factors that may interact with and influence health in people aging with HIV. The data for the first 353 participants are presented, focusing on sociodemographic factors, comorbidities, coinfections, frailty, cognitive function, loneliness, and resilience using a sex/gender stratified analysis. The cohort thus far is 91% men and the median age is 70 years (range from 65 to 85). Several vulnerabilities were observed, including a high prevalence of comorbidities and frailty. Women especially faced financial insecurity and precarious social structures; a large proportion live alone and only 6% are married or in steady relationships. Identifying strategies to address these vulnerabilities will empower people aging with HIV to optimize their health, quality of life, and independence.

Funder

Canadian Institutes of Health Research

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/2/517/pdf

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