Feasibility Analysis of ECG-Based pH Estimation for Asphyxia Detection in Neonates

Author:

Hussain Nadia Muhammad12ORCID,Amin Bilal123ORCID,McDermott Barry James13ORCID,Dunne Eoghan123ORCID,O’Halloran Martin123,Elahi Adnan12ORCID

Affiliation:

1. Electrical and Electronic Engineering, University of Galway, H91 TK33 Galway, Ireland

2. Translational Medical Device Lab, University of Galway, H91 TK33 Galway, Ireland

3. School of Medicine, University of Galway, H91 TK33 Galway, Ireland

Abstract

Birth asphyxia is a potential cause of death that is also associated with acute and chronic morbidities. The traditional and immediate approach for monitoring birth asphyxia (i.e., arterial blood gas analysis) is highly invasive and intermittent. Additionally, alternative noninvasive approaches such as pulse oximeters can be problematic, due to the possibility of false and erroneous measurements. Therefore, further research is needed to explore alternative noninvasive and accurate monitoring methods for asphyxiated neonates. This study aims to investigate the prominent ECG features based on pH estimation that could potentially be used to explore the noninvasive, accurate, and continuous monitoring of asphyxiated neonates. The dataset used contained 274 segments of ECG and pH values recorded simultaneously. After preprocessing the data, principal component analysis and the Pan–Tompkins algorithm were used for each segment to determine the most significant ECG cycle and to compute the ECG features. Descriptive statistics were performed to describe the main properties of the processed dataset. A Kruskal–Wallis nonparametric test was then used to analyze differences between the asphyxiated and non-asphyxiated groups. Finally, a Dunn–Šidák post hoc test was used for individual comparison among the mean ranks of all groups. The findings of this study showed that ECG features (T/QRS, T Amplitude, Tslope, Tslope/T, Tslope/|T|, HR, QT, and QTc) based on pH estimation differed significantly (p < 0.05) in asphyxiated neonates. All these key ECG features were also found to be significantly different between the two groups.

Funder

Science Foundation Ireland

Irish Centre for Fetal and Neonatal Translational Research

Publisher

MDPI AG

Reference76 articles.

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4. Abdo, R.A., Halil, H.M., Kebede, B.A., Anshebo, A.A., and Gejo, N.G. (2019). Prevalence and contributing factors of birth asphyxia among the neonates delivered at Nigist Eleni Mohammed memorial teaching hospital, Southern Ethiopia: A cross-sectional study. BMC Pregnancy Childbirth, 19.

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