Evaluation of Galectin-3 in Dogs with Atrial Fibrillation

Author:

Arcuri Giulia1ORCID,Valente Carlotta1ORCID,Romito Giovanni2ORCID,Bonsembiante Federico1ORCID,Mazzoldi Chiara2,Contiero Barbara1ORCID,Poser Helen1ORCID,Guglielmini Carlo1ORCID

Affiliation:

1. Department of Animal Medicine, Production and Health, University of Padua, 35020 Padua, Italy

2. Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy

Abstract

Galectin-3 (Gal-3) is a lectin associated with fibrosis and inflammation, and increased circulating concentrations are considered a risk factor for atrial fibrillation (AF) in humans. This retrospective study aimed to evaluate the serum concentration of Gal-3 in dogs with cardiac disease, both with and without AF. Dogs with AF associated with acquired heart diseases were selected, while cardiac healthy dogs and dogs with heart diseases but without AF served as controls. We statistically compared the serum concentration of Gal-3, which was assessed using a commercial canine-specific ELISA kit, among healthy dogs and dogs with heart disease with and without AF. Additionally, associations between Gal-3 and clinical and echocardiographic variables were evaluated. A total of 73 dogs were included, of which 17/73 (23.3%) were cardiac healthy and 56/73 (76.7%) had heart disease, with 26/56 (46.4%) having AF. No significant difference in Gal-3 concentration was found between cardiac healthy dogs (3.90 ± 1.65 ng/mL) and dogs with heart disease, either with or without AF (3.37 ± 1.04 ng/mL, p = 0.436 and 4.68 ± 1.80 ng/mL, p = 0.332, respectively). Gal-3 showed a significant positive correlation with age (r = 0.47, p < 0.001) and a negative correlation with body weight (r = −0.45, p < 0.001). The results of this study suggest that Gal-3 does not have an important role in the development of AF in dogs, but it is associated with advanced age.

Funder

University of Padua

Publisher

MDPI AG

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