Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

Author:

Zannella Carla,Shinde Surbhi,Vitiello Mariateresa,Falanga AnnaritaORCID,Galdiero EmiliaORCID,Fahmi Amir,Santella Biagio,Nucci LudovicaORCID,Gasparro Roberta,Galdiero Marilena,Boccellino Mariarosaria,Franci Gianluigi,Di Domenico Marina

Abstract

(1) Background: In dentistry, silver nanoparticles (AgNPs) have progressively earned great interest as antimicrobial drugs and are widely used in several biomedical fields. Recent progress in the analysis of complex bacterial communities has demonstrated the richness of the oral microbiota and the presence of numerous previously unexplained strains. Several efforts have been dedicated to the investigation of antimicrobial peptides (AMPs). Those peptides are a widespread group of small peptides against invading microbes. We report the production of a hybrid molecule composed of AgNPs and indolicidin, a well-known antibacterial peptide. (2) Methods: Spectroscopy and microscopy were used to analyze the optical features and to determine the size of the generated AgNPs. The AgNP antibacterial activity was evaluated versus oral Gram-positive and Gram-negative bacteria. (3) Results: The coated nanoparticles’ antibacterial activity strongly inhibited the growth of microorganisms, with very low minimum inhibitory concentration (MIC) values in the range of 5–12.5 μg/mL. We hypothesize that this effect depended on the specific characteristics of the metal surface coated with indolicidin. The second result was that the coated nanoparticles observed cellular toxicity, was lower with respect to the toxicity of peptide and the naked AgNPs when used individually. (4) New investigations regarding antimicrobial effect of AgNPs coated with AMPs in oral infections are an urgent task.

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Reference61 articles.

1. NF-κB as a potential therapeutic target in microbial diseases

2. Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria

3. Oral probiotics influence oral and respiratory tract infections in pediatric population: A randomized double-blinded placebo-controlled pilot study;Campanella;Eur. Rev. Med. Pharmacol. Sci.,2018

4. Oral microbiomes: More and more importance in oral cavity and whole body;Gal;Protein Cell,2018

5. Antimicrobial Peptides: Old Molecules with New Ideas

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