Abstract
Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, vesiculobullous, and inflammatory conditions should be ruled out. Biopsy and clinicopathologic correlation are required to differentiate between EPD and these entities. A dysregulated, chronic immune response is considered central to the etiopathogenesis of EPD. We performed an evidence-based systematic review of the management options. There were predominantly studies with level IV and V evidence and only two with level III. Despite the responsiveness of EPD to potent topical steroids, such as clobetasol propionate, recurrence occurs after treatment withdrawal. With the available data, tacrolimus 0.1%, curettage-assisted aminolevulinic acid-photodynamic therapy, and systemic retinoids can be considered second-line options for EPD with a role in maintenance regimens. However, controlled data and more powerful studies are needed to make solid recommendations.
Subject
Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics
Reference100 articles.
1. Case for diagnosis. Pustular dermatosis of scalp;Burton;Br. J. Dermatol.,1977
2. Erosive pustular dermatosis of the scalp;Pye;Br. J. Dermatol.,1979
3. Erosive pustular dermatosis of the scalp: Challenges and solutions;Starace;Clin. Cosmet. Investig. Dermatol.,2019
4. Erosive pustular dermatosis (chronic atrophic dermatosis of the scalp and extremities);Semkova;Clin. Cosmet. Investig. Dermatol.,2013
5. Therapeutic options for erosive pustular dermatosis of the scalp: A systematic review;Junejo;Br. J. Dermatol.,2021
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献