Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis

Author:

Villalba Silva Gerda Cristal,Steindorff Thiago,Silvestri Schuh RoselenaORCID,Cardoso Flores Natalia,Matte UrsulaORCID

Abstract

Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we used the CMAP and LINCS databases. For molecular docking, we used the DockThor web server. Our results suggest that pirfenidone and colchicine are promising drugs to treat cardiovascular disease in MPS patients. We also provide a brief description of good practices for the repositioning analysis. Furthermore, the list of drugs and related MPS-enriched genes could be helpful to new treatments and considered for pathophysiological studies.

Funder

Hospital de Clínicas de Porto Alegre

FIPE

Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

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