Affiliation:
1. Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO), Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03690 Alicante, Spain
Abstract
The synthesis of methyl 3,3-bis[4-(dimethylamino)phenyl]-2,2-dimethylpropanoate is achieved by means of the alkylation of methyl isobutyrate silyl enol ether with bis[4-(dimethylamino)phenyl]methanol, facilitated by using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent and reaction promoter. The reaction proceeds smoothly to produce the mentioned compound in a good yield via a metal and additive-free procedure. The corresponding ester is fully characterized.
Funder
Spanish Ministerio de Ciencia y Innovación
Conselleria d’Innovació, Universitats, Ciència i Societat Digital de la Generalitat Valenciana
University of Alicante
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry