Affiliation:
1. Department of Pediatrics, Quillen College of Medicine, Johnson City, TN 37614, USA
Abstract
The worldwide prevalence of type 2 diabetes (T2D) and prediabetes is rapidly increasing, particularly in children, adolescents, and young adults. Oxidative stress (OxS) has emerged as a likely initiating factor in T2D. Natural antioxidant products may act to slow or prevent T2D by multiple mechanisms, i.e., (1) reducing mitochondrial oxidative stress, (2) preventing the damaging effects of lipid peroxidation, and (3) acting as essential cofactors for antioxidant enzymes. Natural antioxidant products should also be evaluated in the context of the complex physiological processes that modulate T2D-OxS such as glycemic control, postprandial OxS, the polyol pathway, high-calorie, high-fat diets, exercise, and sleep. Minimizing processes that induce chronic damaging OxS and maximizing the intake of natural antioxidant products may provide a means of preventing or slowing T2D progression. This “optimal redox” (OptRedox) approach also provides a framework in which to discuss the potential benefits of natural antioxidant products such as vitamin E, vitamin C, beta-carotene, selenium, and manganese. Although there is a consensus that early effective intervention is critical for preventing or reversing T2D progression, most research has focused on adults. It is critical, therefore, that future research include pediatric populations.
Funder
National Institutes of Health
East Tennessee State University Robert W. Summers Pediatric Research Endowmen
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference123 articles.
1. WHO (2022, July 12). Diabetes. Available online: https://www.who.int/news-room/fact-sheets/detail/diabetes.
2. The worldwide epidemiology of type 2 diabetes mellitus—Present and future perspectives;Chen;Nat. Rev. Endocrinol.,2011
3. Trends in Prediabetes Among Youths in the US From 1999 Through 2018;Liu;JAMA Pediatr.,2022
4. (2022, July 13). How Type 2 Diabetes Affects Your Workforce, Available online: https://www.cdc.gov/diabetes/prevention/how-type2-affects-workforce.htm#:~:text=Diabetes%20Is%20Costly,over%20a%205%2Dyear%20period.
5. Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement;Davidson;JAMA,2021
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献