Abstract
The term “cytokine storm” describes an acute pathophysiologic state of the immune system characterized by a burst of cytokine release, systemic inflammatory response, and multiple organ failure, which are crucial determinants of many disease outcomes. In light of the complexity of cytokine storms, specific strategies are needed to prevent and alleviate their occurrence and deterioration. Nuclear factor erythroid 2-related factor 2 (NRF2) is a CNC-basic region-leucine zipper protein that serves as a master transcription factor in maintaining cellular redox homeostasis by orchestrating the expression of many antioxidant and phase II detoxification enzymes. Given that inflammatory response is intertwined with oxidative stress, it is reasonable to assume that NRF2 activation limits inflammation and thus cytokine storms. As NRF2 can mitigate inflammation at many levels, it has emerged as a potential target to prevent and treat cytokine storms. In this review, we summarized the cytokine storms caused by different etiologies and the rationale of interventions, focusing mainly on NRF2 as a potential therapeutic target.
Funder
National Natural Science Foundation of China
National Key R&D Program of China of the Ministry of Science and Technology of the People’s Republic of China
Natural Science Foundation of Liaoning Province
Shenyang Science and Technology Bureau of Support Program for Young Innovation Scholar
China Medical University
High-level Talents Support Foundation from China Medical University
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
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