Resveratrol Mitigates Metabolism in Human Microglia Cells

Author:

Schlotterose Luise1ORCID,Pravdivtseva Mariya S.2ORCID,Ellermann Frowin2ORCID,Jansen Olav3,Hövener Jan-Bernd2ORCID,Sönnichsen Frank D.4ORCID,Cossais François1,Lucius Ralph1,Hattermann Kirsten1ORCID

Affiliation:

1. Institute of Anatomy, Kiel University, 24118 Kiel, Germany

2. Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, 24105 Kiel, Germany

3. Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany

4. Otto Diels Institute for Organic Chemistry, Kiel University, 24118 Kiel, Germany

Abstract

The recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. There is growing evidence that the uncontrolled and persisting activation of microglial cells is involved in the progression of diseases such as Alzheimer’s or Parkinson’s disease. The inflammatory activation of microglia cells is often accompanied by a switch in metabolism to higher glucose consumption and aerobic glycolysis. In this study, we investigate the changes induced by the natural antioxidant resveratrol in a human microglia cell line. Resveratrol is renowned for its neuroprotective properties, but little is known about its direct effect on human microglia cells. By analyzing a variety of inflammatory, neuroprotective, and metabolic aspects, resveratrol was observed to reduce inflammasome activity, increase the release of insulin-like growth factor 1, decrease glucose uptake, lower mitochondrial activity, and attenuate cellular metabolism in a 1H NMR-based analysis of whole-cell extracts. To this end, studies were mainly performed by analyzing the effect of exogenous stressors such as lipopolysaccharide or interferon gamma on the metabolic profile of microglial cells. Therefore, this study focuses on changes in metabolism without any exogenous stressors, demonstrating how resveratrol might provide protection from persisting neuroinflammation.

Funder

the German Research Foundation

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

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