Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice-Reference-Cited by-同舟云学术

Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

Published:2023-06-11 Issue:6 Volume:12 Page:1258
ISSN:2076-3921
Container-title:Antioxidants
language:en
Short-container-title:Antioxidants

Author:

Barbosa-de-Oliveira Maria Clara¹,Oliveira-Melo Paolo²,Gonçalves da Silva Marcos Henrique³,Santos da Silva Flávio¹^ORCID,Andrade Carvalho da Silva Felipe¹,Silva de Araujo Bruno Vinicios¹^ORCID,Franco de Oliveira Moacir⁴,Tadeu Correia Aristides²,Miyoshi Sakamoto Sidnei¹^ORCID,Valença Samuel Santos⁵^ORCID,Lanzetti Manuella⁵^ORCID,Schmidt Martina⁶⁷^ORCID,Kennedy-Feitosa Emanuel¹

Affiliation:

1. Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil

2. Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo, Sao Paulo 05508-220, Brazil

3. Department of Clinical Medicine, Federal Fluminense University (UFF), Niterói 24000-000, Brazil

4. Department of Animal Science, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil

5. Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-590, Brazil

6. Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Building 3211, Room 406, 9713 AV Groningen, The Netherlands

7. Groningen Research Institute of Asthma and COPD, GRIAC, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands

Abstract

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

Funder

Universidade Federal Rural do Semi-Árido

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

Link

https://www.mdpi.com/2076-3921/12/6/1258/pdf

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