Intra-Species Variations of Bioactive Compounds of Two Dictyota Species from the Adriatic Sea: Antioxidant, Antimicrobial, Dermatological, Dietary, and Neuroprotective Potential
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Published:2023-04-01
Issue:4
Volume:12
Page:857
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Martić Ana1, Čižmek Lara12ORCID, Ul’yanovskii Nikolay V.3, Paradžik Tina4ORCID, Perković Lucija1, Matijević Gabrijela1, Vujović Tamara1, Baković Marija1, Babić Sanja12ORCID, Kosyakov Dmitry S.3ORCID, Trebše Polonca5ORCID, Čož-Rakovac Rozelindra12
Affiliation:
1. Laboratory for Aquaculture Biotechnology, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia 2. Center of Excellence for Marine Bioprospecting (BioProCro), Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia 3. Laboratory of Natural Compounds Chemistry and Bioanalytics, Northern (Arctic) Federal University, Nab. Severnoy Dviny 17, 163002 Arkhangelsk, Russia 4. Laboratory for Chemical and Biological Crystallography, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia 5. Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, 1000 Ljubljana, Slovenia
Abstract
The marine environment has a significant impact on life on Earth. Organisms residing in it are vital for the ecosystem but also serve as an inexhaustible source of biologically active compounds. Herein, the biodiversity of two brown seaweeds, Dictyota dichotoma and Dictyota fasciola from the Adriatic Sea, was evaluated. The aim of the study was the determination of differences in compound composition while comparing their activities, including antioxidant, antimicrobial, and enzyme inhibition, in connection to human digestion, dermatology, and neurological disorders. Chemical analysis revealed several terpenoids and steroids as dominant molecules, while fucoxanthin was the main identified pigment in both algae. D. dichotoma had higher protein, carbohydrate, and pigment content. Omega-6 and omega-3 fatty acids were identified, with the highest amount of dihomo-γ-linolenic acid and α-linolenic acid in D. dichotoma. Antimicrobial testing revealed a dose-dependent inhibitory activity of methanolic fraction against Escherichia coli and Staphylococcus aureus. Moderate antioxidant activity was observed for both algae fractions, while the dietary potential was high, especially for the D. fasciola dichloromethane fraction, with inhibition percentages of around 92% for α-amylase and 57% for pancreatic lipase at 0.25 mg/mL. These results suggest that Dictyota species might be a potent source of naturally derived agents for obesity and diabetes.
Funder
SUPERFOOD-Microalgae to Innovative Bakery Products and Pasta Development of Innovative Biobased Products by in silico Assessment of Microalgae Bioactivity European Union through the European Regional Development Fund-the Competitiveness and Cohesion Operational and Scientific Center of Excellence for Marine Bioprospecting- BioProCro Ministry of Science and Higher Education of the Russian Federation Slovenian Research Agency
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
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