Affiliation:
1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy
2. Department of Biosciences, University of Milan, 20133 Milan, Italy
Abstract
Glutathione (GSH) has special antioxidant properties due to its high intracellular concentration, ubiquity, and high reactivity towards electrophiles of the sulfhydryl group of its cysteine moiety. In most diseases where oxidative stress is thought to play a pathogenic role, GSH concentration is significantly reduced, making cells more susceptible to oxidative damage. Therefore, there is a growing interest in determining the best method(s) to increase cellular glutathione for both disease prevention and treatment. This review summarizes the major strategies for successfully increasing cellular GSH stores. These include GSH itself, its derivatives, NRf-2 activators, cysteine prodrugs, foods, and special diets. The possible mechanisms by which these molecules can act as GSH boosters, their related pharmacokinetic issues, and their advantages and disadvantages are discussed.
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference142 articles.
1. Glutathione homeostasis and functions: Potential targets for medical interventions;Lushchak;J. Amino Acids,2012
2. Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers;Giustarini;Crit. Rev. Clin. Lab. Sci.,2009
3. Direct determination of thiol pKa by isothermal titration microcalorimetry;Tajc;J. Am. Chem. Soc.,2004
4. Glutathione: Overview of its protective roles, measurement, and biosynthesis;Forman;Mol. Asp. Med.,2009
5. Kinetic studies on the removal of extracellular hydrogen peroxide by cultured fibroblasts;Makino;J. Biol. Chem.,1994
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