The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways
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Published:2023-12-01
Issue:12
Volume:12
Page:2067
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Lazzarin Taline1ORCID, Martins Danilo1ORCID, Ballarin Raquel S.1ORCID, Monte Marina G.1ORCID, Minicucci Marcos F.1, Polegato Bertha F.1ORCID, Zornoff Leonardo1
Affiliation:
1. Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18600-000, Brazil
Abstract
Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest clinically as alterations in the size, shape, and function of the heart. Despite the pharmacological approaches, cardiac remodeling-related mortality rates remain high. Therefore, other therapeutic options are being increasingly studied. This review highlights the role of omega-3 as an adjunctive therapy to attenuate cardiac remodeling, with an emphasis on its antioxidant and anti-inflammatory actions.
Funder
National Council for Scientific and Technological Development
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference63 articles.
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