Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
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Published:2023-06-09
Issue:6
Volume:12
Page:1243
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Spasova Mariya1ORCID, Stoyanova Nikoleta1, Nachev Nasko1ORCID, Ignatova Milena1ORCID, Manolova Nevena1ORCID, Rashkov Iliya1ORCID, Georgieva Ani2, Toshkova Reneta2, Markova Nadya3
Affiliation:
1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria 2. Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 25, BG-1113 Sofia, Bulgaria 3. Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 26, BG-1113 Sofia, Bulgaria
Abstract
A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction with electrospraying. Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), water contact angle measurements and ultraviolet-visible spectroscopy (UV-Vis) were used for the complex characterization of the obtained novel material. The decoration of CA fibers with a water-soluble polymer containing the drug resulted in the facilitation of wetting and fast drug release. The 5N-containing fibrous material showed antioxidant activity. Moreover, the proposed materials’ antibacterial and antifungal properties were tested against S. aureus, E. coli, P. aeruginosa and C. albicans. Well-distinguished, sterile zones with diameters above 3.5 cm were observed around all 5N-containing mats. The mats’ cytotoxicity toward HeLa carcinoma cells and normal mouse BALB/c 3T3 fibroblasts was assessed. The 5N-in-CA, PVP,5N-on-(5N-in-CA) and PVA,5N-on-(5N-in-CA) fibrous mats possessed anticancer efficacies and much lower levels of toxicity against normal cells. Therefore, the as-created novel electrospun materials, which are based on polymers loaded with the drug 5N via electrospinning/electrospraying, can potentially be applied for topical wound healing and for local cancer therapy.
Funder
Bulgarian National Science Fund
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
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