Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy

Author:

Ortega Miguel A.ORCID,Fraile-Martinez OscarORCID,García-Montero CieloORCID,Rodriguez-Martín Sonia,Funes Moñux Rosa M.,Bravo Coral,De Leon-Luis Juan A.ORCID,Saz Jose V.,Saez Miguel A.ORCID,Guijarro Luis G.,Lahera GuillermoORCID,Monserrat JorgeORCID,Mora FernandoORCID,Quintero JavierORCID,Bujan JuliaORCID,García-Honduvilla NatalioORCID,Alvarez-Mon MelchorORCID,Alvarez-Mon Miguel AngelORCID

Abstract

Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients.

Funder

Instituto de Salud Carlos III

the European Development Regional Fund “A way to achieve Europe”

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

Reference63 articles.

1. Calabrese, J., and Khalili, Y. (2022). Al Psychosis, StatPearls.

2. Psychotic Disorders in DSM-5: Summary of Changes;Carpenter;Asian J. Psychiatr.,2013

3. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5®), American Psychiatric Association.

4. Recognition and Differential Diagnosis of Psychosis in Primary Care;Griswold;Am. Fam. Physician,2015

5. Focus on Psychosis;Gaebel;Dialogues Clin. Neurosci.,2015

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3