Affiliation:
1. Department for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, Italy
2. Department of Pharmacy and Biotechnology, Alma Mater Studiorum–University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Abstract
Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard features and mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress and inflammation. As there are no effective treatments to counteract neurodegenerative diseases, increasing interest has been directed to the potential neuroprotective activities of plant-derived compounds found abundantly in food and in agrifood by-products. Food waste has an extremely negative impact on the environment, and recycling is needed to promote their disposal and overcome this problem. Many studies have been carried out to develop green and effective strategies to extract bioactive compounds from food by-products, such as peel, leaves, seeds, bran, kernel, pomace, and oil cake, and to investigate their biological activity. In this review, we focused on the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates.
Funder
Alma Idea 2022, Line B, University of Bologna
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference325 articles.
1. GBD 2017 Causes of Death Collaborators (2018). Global, Regional, and National Age-Sex-Specific Mortality for 282 Causes of Death in 195 Countries and Territories, 1980–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1736–1788.
2. Callens, M., Loncke, J., and Bultynck, G. (2022). Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome. Cells, 11.
3. Basic Mechanisms of Neurodegeneration: A Critical Update;Jellinger;J. Cell Mol. Med.,2010
4. Angeloni, C., Malaguti, M., Barbalace, M.C., and Hrelia, S. (2017). Bioactivity of Olive Oil Phenols in Neuroprotection. Int. J. Mol. Sci., 18.
5. Molecular and Cellular Pathways of Neurodegeneration in Motor Neurone Disease;Shaw;J. Neurol. Neurosurg. Psychiatry,2005