Affiliation:
1. Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO), Facultad de Ciencias, Universidad de Alicante, Apdo. 99, E-03690 Alicante, Spain
Abstract
The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under a metal and additive-free procedure. The corresponding allylated phenol has been fully characterized.
Funder
Spanish Ministerio de Ciencia y Innovación
Conselleria d’Innovació, Universitats, Ciència i Societat Digital de la Generalitat Valenciana
University of Alicante
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry