Author:
Ricklefs Franz L.,Maire Cecile L.,Matschke Jakob,Dührsen Lasse,Sauvigny Thomas,Holz Mareike,Kolbe Katharina,Peine Sven,Herold-Mende Christel,Carter Bob,Chiocca E. Antonio,Lawler Sean E.,Westphal Manfred,Lamszus Katrin
Abstract
Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
Funder
Deutsche Forschungsgemeinschaft
National Cancer Institute
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
24 articles.
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