Bredigite-CNTs Reinforced Mg-Zn Bio-Composites to Enhance the Mechanical and Biological Properties for Biomedical Applications

Abstract

Magnesium (Mg) and its compounds have been investigated as biodegradable metals for bone implants. However, high corrosion rates and low bioactivity that cause loss of mechanical properties are factors that have limited their biomedical applications. The purpose of this work is to remedy the weaknesses of the Mg–Zn (MZ) alloy matrix. For this purpose, we have synthesized Mg-based composites with different concentrations of bredigite (Br; Ca7MgSi4O16)–carbon nanotubes (CNTs) using mechanical alloying and semi-powder metallurgy processes with spark plasma sintering. Then, we studied the effect of the simultaneous addition of Br-CNTs on in vitro degradation, as well as its effect on the composites’ mechanical and antibacterial properties. Increases of 57% and 72% respectively were observed in the microhardness and compressive strength of the MZ/Br-CNTs composite in comparison to the MZ alloy. In addition, the rate of degradation of Mg-based composites in simulated body fluids (SBF) was almost 2 times lower. An assessment of antibacterial behavior disclosed that the simultaneous adding of Br-CNTs to Mg can meaningfully prevent the growth and invasion of E. coli and S. aureus. These research findings demonstrate the potential application of MZ/Br-CNTs composites to implants and the treatment of bone infections.