Author:
Xu Wenjiao,Fang Yuwen,Hu Qiao,Zhu Kui
Abstract
Probiotics have been associated with clinical infections, toxicity, and antimicrobial resistance transfer, raising public concerns. Probiotic enterococci are emerging food risks as opportunistic pathogens, yet little attention has been paid to them. Herein, we collected 88 enterococcal isolates from probiotic products used for humans, companion animals, livestock, and aquaculture. Results showed that all 88 probiotic enterococcal isolates harbored diverse virulence genes, multiple antimicrobial resistance genes, and mobile genetic elements. Notably, 77 isolates were highly resistant to gentamicin. Representative enterococcal isolates exerted toxic activities in both in vitro and in vivo models. Collectively, our findings suggest that probiotic enterococci may be harmful to hosts and pose a potential threat to public health.
Funder
the National Key Research and Development Program of China; Beijing Municipal Science and Technology Commission
Subject
Plant Science,Health Professions (miscellaneous),Health(social science),Microbiology,Food Science
Cited by
8 articles.
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