Long Non-Coding RNAs in Sjögren’s Disease-Reference-Cited by-同舟云学术

Long Non-Coding RNAs in Sjögren’s Disease

Published:2024-05-09 Issue:10 Volume:25 Page:5162
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Pastva Ondřej¹²^ORCID,Klein Kerstin¹²^ORCID

Affiliation:

1. Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, 3008 Bern, Switzerland

2. Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland

Abstract

Sjögren’s disease (SjD) is a heterogeneous autoimmune disease characterized by severe dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain. Chronic inflammation of the salivary and lacrimal glands, auto-antibody formation, and extra-glandular manifestations occur in subsets of patients with SjD. An aberrant expression of long, non-coding RNAs (lncRNAs) has been described in many autoimmune diseases, including SjD. Here, we review the current literature on lncRNAs in SjD and their role in regulating X chromosome inactivation, immune modulatory functions, and their potential as biomarkers.

Funder

University of Bern

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/10/5162/pdf

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