Predominance of Dengue Virus Serotype-1/Genotype-I in Eastern and Southeastern Ethiopia-Reference-Cited by-同舟云学术

Predominance of Dengue Virus Serotype-1/Genotype-I in Eastern and Southeastern Ethiopia

Published:2024-08-21 Issue:8 Volume:16 Page:1334
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Tsegaye Mesfin Mengesha¹²^ORCID,Mekonnen Adamu Tayachew³^ORCID,Gebretsion Daniel Tsega³^ORCID,Gelanew Tesfaye¹^ORCID,Alemayehu Dawit Hailu¹,Tefera Dessalegn Abeje¹^ORCID,Woldemichael Tamirayehu Seyoum¹,Getaneh Bethlehem Adnew¹,Abera Eleni Kidane³,Jebessa Gadissa Gutema³^ORCID,Korkiso Asefa Konde³,Tessema Mengistu Biru³,Asfaw Admikew Agunie³,Temre Yoseph Asrat³^ORCID,Wossen Mesfin³,Piantadosi Anne⁴^ORCID,Zhu Huachen²^ORCID,Abdissa Alemseged¹,Mihret Adane¹,Mulu Andargachew¹^ORCID

Affiliation:

1. Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia

2. State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong SAR 999077, China

3. Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia

4. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA

Abstract

We determined the dengue virus (DENV) serotypes and genotypes in archived serum samples that were collected during the 2014–2016 and 2021 dengue outbreaks in Dire Dawa City and the Somali region in Ethiopia. DENV serotype 1 (DENV-1) was predominant followed by DENV serotype 2 (DENV-2). Thirteen of the DENV-1 strains were assigned to Genotype-I, while the remaining two were found to be Genotype-III. All three DENV-2 strains were assigned the Cosmopolitan Genotype. The DENV strains responsible for the outbreaks are genetically closely related to the DENV strains that circulated in neighboring and Asian countries. The findings also showed continued local transmission of a monophyletic lineage and a co-circulation of DENV-1 and DENV-2 during the outbreaks. There is a need to strengthen DENV genomic surveillance capacity for the early detection of circulating serotypes, and prevent devastating consequences of future outbreaks due to the co-circulation of different serotypes.

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/8/1334/pdf

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