Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Author:

Choi Na-Ri12ORCID,Choi Woo-Gyun1ORCID,Lee Jong-Hwan3,Park Joon45,Kim Yun-Tai45ORCID,Das Raju6,Woo Joo-Han6ORCID,Kim Byung-Joo1

Affiliation:

1. Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea

2. Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea

3. Department of Biomedical Engineering, College of Engineering, Dong-Eui University, Busan 47340, Republic of Korea

4. Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea

5. Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea

6. Department of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea

Abstract

(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na+ (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.

Funder

Ministry of Health & Welfare, Republic of Korea

Publisher

MDPI AG

Reference39 articles.

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4. The Metabolism of Polysaccharide from Atractylodes macrocephala Koidz and Its Effect on Intestinal Microflora;Wang;Evid. Based Complement. Altern. Med.,2014

5. Effects of Atractylodes macrocephala monosaccharide composition on cytodifferentiation and villin expression of IEC-6 cells in vitro;Wang;J. Chin. Med. Mater,2010

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