Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy-Reference-Cited by-同舟云学术

Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy

Published:2023-05-31 Issue:11 Volume:24 Page:9593
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Iizuka Yuki¹,Manabe Yoshiyuki¹²³^ORCID,Ooe Kazuhiro⁴,Toyoshima Atsushi³,Yin Xiaojie⁵,Haba Hiromitsu⁵,Kabayama Kazuya¹²³,Fukase Koichi¹²³⁶^ORCID

Affiliation:

1. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, Japan

2. Forefront Research Center, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, Japan

3. Division of Science, Institute for Radiation Sciences, Osaka University, 1-1 Machikaneyama, Toyonaka 560-0043, Osaka, Japan

4. Radioisotope Research Center, Institute for Radiation Sciences, Osaka University, 2-4 Yamadaoka, Suita 565-0871, Osaka, Japan

5. RIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako 351-0198, Saitama, Japan

6. Center for Advanced Modalities and DDS, Osaka University, 1-1 Yamadaoka, Suita 565-0871, Osaka, Japan

Abstract

Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver 211At (α-particle emitter) to the nuclei of cancer cells. The developed 211At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery.

Funder

JSPS KAKENHI

JST CREST

AMED

JST FOREST Program

QiSS program of the OPERA

Japan Initiative for World-leading Vaccine Research and Development Centers

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/11/9593/pdf

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