Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System-Reference-Cited by-同舟云学术

Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

Published:2023-05-30 Issue:11 Volume:24 Page:9466
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Zagitova Renata I.¹^ORCID,Purtov Konstantin V.²,Shcheglov Aleksandr S.¹³,Mineev Konstantin S.¹⁴^ORCID,Dubinnyi Maxim A.¹⁴^ORCID,Myasnyanko Ivan N.¹³,Belozerova Olga A.¹^ORCID,Pakhomova Vera G.⁵,Petushkov Valentin N.²,Rodionova Natalia S.²,Lushpa Vladislav A.¹⁴,Guglya Elena B.¹³^ORCID,Kovalchuk Sergey¹,Kozhemyako Valeri B.⁶,Mirza Jeremy D.⁷,Oliveira Anderson G.⁸^ORCID,Yampolsky Ilia V.¹³,Kaskova Zinaida M.¹³^ORCID,Tsarkova Aleksandra S.¹³^ORCID

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, Russia

2. Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, Akademgorodok 50/50, 660036 Krasnoyarsk, Russia

3. Institute of Translational Medicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia

4. Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, 141700 Moscow, Russia

5. Federal Research Center “Krasnoyarsk Science Center SB RAS”, Akademgorodok 50, 660036 Krasnoyarsk, Russia

6. Central Research Laboratory, Pacific State Medical University, Ostryakova 2, 690002 Vladivostok, Russia

7. School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

8. Department of Chemistry and Biochemistry, Yeshiva University, 245 Lexington Ave, New York, NY 10016, USA

Abstract

Biochemistry of bioluminescence of the marine parchment tubeworm Chaetopterus has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from Chaetomorpha linum algae, which demonstrate bioluminescence activity with Chaetopterus luciferase in the presence of Fe2+ ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/11/9466/pdf

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