Author:
Chen Yue-Hua,Rao Zhou-Feng,Liu Yu-Jie,Liu Xiang-Sheng,Liu Yu-Fei,Xu Lan-Ju,Wang Ze-Qi,Guo Jing-Yue,Zhang Lin,Dong Yun-Sheng,Qi Chun-Xiao,Yang Chao,Wang Shu-Fang
Abstract
Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Natural Science Foundation of Tianjin City
Subject
Molecular Biology,Biochemistry
Cited by
57 articles.
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