Development of Non-Invasive Biosensors for Neonatal Jaundice Detection: A Review
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Published:2024-05-17
Issue:5
Volume:14
Page:254
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ISSN:2079-6374
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Container-title:Biosensors
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language:en
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Short-container-title:Biosensors
Author:
Hazarika Chandan Jyoti1, Borah Alee1, Gogoi Poly1, Ramchiary Shrimanta S.1ORCID, Daurai Bethuel1ORCID, Gogoi Manashjit1ORCID, Saikia Manob Jyoti2ORCID
Affiliation:
1. Department of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya 793022, India 2. Department of Electrical Engineering, University of North Florida, Jacksonville, FL 32224, USA
Abstract
One of the most common problems many babies encounter is neonatal jaundice. The symptoms are yellowing of the skin or eyes because of bilirubin (from above 2.0 to 2.5 mg/dL in the blood). If left untreated, it can lead to serious neurological complications. Traditionally, jaundice detection has relied on invasive blood tests, but developing non-invasive biosensors has provided an alternative approach. This systematic review aims to assess the advancement of these biosensors. This review discusses the many known invasive and non-invasive diagnostic modalities for detecting neonatal jaundice and their limitations. It also notes that the recent research and development on non-invasive biosensors for neonatal jaundice diagnosis is still in its early stages, with the majority of investigations being in vitro or at the pre-clinical level. Non-invasive biosensors could revolutionize neonatal jaundice detection; however, a number of issues still need to be solved before this can happen. These consist of in-depth validation studies, affordable and user-friendly gadgets, and regulatory authority approval. To create biosensors that meet regulatory requirements, additional research is required to make them more precise and affordable.
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