Abstract
The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.
Funder
Asociación Española Contra el Cáncer
Spanish Ministry of Science and Innovation
University of Salamanca and Fundación Memoria de Samuel Solorzano Barruso
Consejería de Educación de la Junta de Castilla y León
Subject
Genetics (clinical),Genetics
Cited by
14 articles.
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